Arrivals / Check-in in hotels

Registration

Welcome
Welcome by Frank P Luyten and Danny Huylebroeck
Promotion Hall, University Hall, 1st floor

Caroline Hill (London)

SNW1 IS A CRITICAL REGULATOR OF SPATIAL BMP ACTIVITY AND NEURAL PLATE BORDER FORMATION IN VERTEBRATE EMBRYOS

Malcolm Moos (Bethesda)
AN EXTRACELLULAR MATRIX-ASSOCIATED BMP ANTAGONIST

16:20-16:40

Peter ten Dijke (Leiden) (A7)

REGULATION OF TGFbeta/BMP SIGNALING BY TRAF 4

Gopal Sapkota (Dundee) (A8)

UNDERSTANDING THE MOLECULAR MECHANISMS BY WHICH BMP SIGNALLING IS REGULATED

Lan Xu (Worcester, MA) (*A9)

A NOVEL SMAD INHIBITION MECHANISM MEDIATED BY THE STE20 KINASE MISSHAPEN

Satoshi Ohte (Saitama) (*A10)

IDENTIFICATION AND CHARACTERIZATION OF A NUCLEAR PROTEIN AS A CO-SUPPRESSOR OF BMP-REGULATED  R-SMADS

Elizabeth Robertson (Oxford)
TGFβ SIGNALING PATHWAYS GOVERNING CELL LINEAGE COMMITMENT IN THE EARLY MAMMALIAN EMBRYO

Reception/ welcome by Mr Louis Tobback, Mayor of the city of Leuven

Walking dinner

Registration

Ye-Guang Chen (Beijing)
GENOME-WIDE ANALYSIS OF SMAD TARGETS REVEALS THE ROLE OF BMP SIGNALING IN MOUSE ES CELL FATE DETERMINATION

Herb Lin (Cambridge, MA)

THE CENTRAL ROLE OF THE BMP CORECEPTOR HEMOJUVELIN IN THE REGULATION OF IRON METABOLISM

09:35-09:50

Hamed Alborzinia (Heidelberg) (*A14) with ESF support

KINETIC ANALYSIS OF BMP-2 ENDOCYTOCIS

Alex Bullock (Oxford) (*A15)

STRUCTURAL INSIGHT INTO ALK2 R206H MUTATION AND INHIBITOR DESIGN FOR FOP

Francesca Giacopelli (Genova) (*A16)

STUDY OF THE ACVR1 GENE EXPRESSION AND REGULATION:
THE PROMOTER REGION AND THE 5'-UTR

Paulo Pereira (Leuven) (*A17)

BMP/SMAD5 SIGNALING ANTAGONIZES NODAL SIGNALING:

A MECHANISM TO PREVENT ECTOPIC PRIMITIVE STREAK FORMATION IN MOUSE

11:00-11:30

Irma Thesleff (Helsinki)
REGULATION OF TOOTH INITIATION AND MORPHOGENESIS BY BMPS

11:30-11:50

An Zwijsen (Leuven)
BMP-SMADS ARE CRITICAL REGULATORS OF BLOOD VESSEL PLASTICITY AND AMNION HOMEOSTASIS IN MOUSE EMBRYOS

11:50-12:05

12:05-12:20

Vesa Kaartinen (Michigan, MI) (A31)

RIGHT VENTRICLE AND OUTFLOW TRACT DEVELOPMENT ARE DEPENDENT ON BMP TYPE I RECEPTOR ALK2 (ACVR1) EXPRESSION BY SECOND HEART FIELD CELLS

12:20-12:30

Emma de Pater (Rotterdam) (*A32) with ESF support

INHIBIOTON OF BMP SIGNALING BY SMAD6 IS REQUIRED FOR TERMINAL DIFFERENTIATION OF VENTRICULAR CARDIOMYOCYTES

Dawn Clendenning (Nashville, TN) (*A33)

INTERACTIONS BETWEEN GDF6, BMP4, AND NOGGIN IN CRANIAL SUTURE AND SKELETAL DEVELOPMENT

Petra Seemann (Berlin) (A34)

INHIBITION OF GDF5 BY NOGGIN IS REQUIRED FOR JOINT DEVELOPMENT

13:00-15:00

Eileen M. Shore (Philadelphia)

MILD HYPER-ACTIVATION OF BMP SIGNALING IN VARIANT FORMS OF FIBRODYSPLASIA OSSIFICANS PROGRESSIVA

Rik Lories (Leuven)
THE DIFFERENT FACES OF BMPS IN CHRONIC ARTHRITIS

Catherine Syddall (Newcastle) (*A43) with ESF support

FUNCTIONAL ANALYSIS OF THE OSTEOARTHRITIS (OA) ASSOCIATED VARIANT rs143383

Geri Gross (Braunschweig) (*A44)

SYSTEMIC RNAi-MEDIATED SILENCING OF TAK1 IS A NOVEL AND EFFICIENT THERAPEUTIC APPROACH FOR RHEUMATOID ARTHRITIS

Robert Martinez (Cambridge, MA) (*A45)

BMP-2/6 HETERODIMER IS MORE OSTEOGENIC THAN BMP-2 AND BINDS STRONGLY TO BOTH THE TYPE I AND TYPE II RECEPTORS

David de Gorter (Leiden) (*A46) with ESF support

BIPHASIC EFFECTS OF TGFbeta ON BMP-INDUCED OSTEOBLAST DIFFERENTIATION

Thomas Crouzier (Grenoble) (*A47) with ESF support

THIN BIOMIMETIC FILMS OF CONTROLLED STIFFNESS AND BIOACTIVITY AS AN INNOVATIVE TOOL TO UNRAVEL BMP-2 EFFECTS ON CELLULAR PROCESSES

Poster Session 1
(participants present posters with odd numbers)

Extra lecture "Beyond the barriers"

Konrad Basler (Zurich)

DPP, GRADIENTS AND GROWTH

08:30-09:00

Slobodan Vukicevic (Zagreb)

REGENERATION OF ORGANS BY BMPS

Kohei Miyazono (Tokyo) (A55)

EFFECTS OF BMP ON VASCULAR ENDOTHELIAL CELLS AND IDENTIFICATION OF TARGET GENES

Gareth Inman (Dundee/Glasgow) (A56)

PRO-PROLIFERATIVE BMP9 SIGNALLING

Marwa Mahmoud (Newcastle) (*A57) with ESF support

MECHANISMS UNDERLYING THE DEVELOPMENT OF ARTERIOVENOUS MALFORMATIONS IN TWO INDICIBLE MOUSE MODELS OF HEREDITARY HAEMORRHAGIC TELANGIECTASIA

Vishwas Paralkar (New London, CT) (A58)

A NOVEL ROLE OF BMP6 AS AN ENDOCRINE REGULATOR OF GLUCOSE HOMEOSTASIS

Caterina Clementi (Houston, TX) (*A59) with ESF support

BMPs AND UTERINE BIOLOGY: THE ROLES OF BMP TYPE I RECEPTORS IN THE PERI-IMPLANTATION PERIOD

Evan Reid (Cambridge, UK) (A60)

UPREGULATED BMP SIGNALING: A COMMON PATHOGENIC MECHANISM FOR AXONAL DEGENERATION?

Stefano Piccolo (Padova)
PATTERNING WITHIN THE SPEMANN ORGANIZER: A GENE NETWORK FOR ANTERO-POSTERIOR SPECIFICATION

Paul Yu (Boston, MA) (A86)

APPLICATIONS OF SMALL MOLECULE BMP INHIBITORS IN PHYSIOLOGY AND DISEASE

Julia Zimmer (Berlin) (*A94) with ESF support

BMP2 VARIANTS WITH REDUCED BMP ANTAGONIST SENSITIVITY FOR IMPROVED REGENERATIVE POTENTIAL

Roberto Ravazzolo (Genova) (*A88)

THE ROLE OF THE 3'-UTR REGION IN THE REGULATION OF THE ACVR1 GENE EXPRESSION

Jan Boergermann (Berlin) (*A89) with ESF support

DORSOMORPHIN AND LDN-193189 INHIBIT BMP-MEDIATED SMAD, P38 AND AKT SIGNALLING IN C2C12 CELLS

Jennifer Heinke (Freiburg) (*A90) with ESF support

BMP MODULATOR BMPER IS HIGHLY EXPRESSED IN MALIGNANT TUMORS AND CONTROLS INVASIVE CELL BEHAVIOR

Olexandr Korchynskyi (Amsterdam) (A91)

TIEG1 AND TWIST1 INTEGRATE PROINFLAMMATORY AND BMP EFFECTS ON THE SKELETON AND BRAIN FORMATION

Christine Mummery (Leiden)
PLURIPOTENT STEM CELLS AS CARDIOVASCULAR DISEASE MODELS

Ugo Ripamonti (Witwatersrand, Parktown) (*A103)

THE INDUCTION OF CEMENTOGENESIS AND PERIODONTAL LIGAMENT REGENERATION BY BONE MORPHOGENETIC/OSTEOGENIC PROTEINS IN NON-HUMAN PRIMATE MODELS

Yu-Hua Tseng (Boston, MA) (*A97)

BMP7 DRIVES BROWN ADIPOGENESIS IN TISSUE RESIDENT PROGENITORS

Mihaela Crisan (Rotterdam) (*A98) with ESF support

ROLE OF BMP4 AND HEDGEHOG FACTORS DURING HEMATOPOIETIC DEVELOPMENT IN MOUSE EMBRYO

Steven Goossens (Gent) (*A99) with ESF support

SIP 1 IS ESSENTIAL FOR MURINE EMBRYONIC HEMATOPOIETIC STEM/PROGENITOR CELL DIFFERENTIATION AND MOBILIZATION

Shirley Motaung (Pretoria) (*A100)

INDUCTION OF EXPRESSION OF SUPERFICIAL ZONE PROTEIN (SZP) IN MUSCLE-DERIVED MESENCHYMAL PROGENITORS/STEM CELLS BY TGFbeta-1 and BMP-7

Esmeralda Blaney-Davidson (Nijmegen) (*A101) with ESF support

SMAD 2/3 SIGNALING IS CRUCIAL FOR CARTILAGE MAINTENANCE, WHEREAS SMAD 1/5/8 SIGNALING DETERMINES CHONDROCYTE TERMINAL DIFFERENTIATION

Vladimir Botchkarev (Boston, MA / Bradford) (*A102)

OVEREXPRESSION OF SMAD1 IN THE SKIN IMPAIRS POSTNATAL HAIR CYCLING, WOUND HEALING AND PREVENTS TUMOR FORMATION VIA FUNCTIONAL RESTRICTION OF EPITHELIAL STEM CELLS

Laurent Obert (Besancon) (A135)

PRELIMINARY PROSPECTIVE MONOCENTRIC COHORT TO EVALUATE THE SAFETY AND THE EFFECT OF RH BMP7 IN RESISTANT LONG BONE NON UNION

(participants present posters with even numbers)

Extra lecture "Beyond the barriers"
Thomas Braun (Bad Nauheim)
SIGNALING IN THE SPECIFICATION MYOCARDIAL LAYERS AND THE REMODELING OF THE CARDIOVASCULAR SYSTEM

Enrique Gómez-Barrena (Madrid)

BMPS IN TRAUMA AND ORTHOPAEDIC SURGERY: PRESENT AND FUTURE

Peter Giannoudis (Leeds)

TREATMENT OF LONG BONE NON-UNIONS WITH BMPS

Ulf Wikesjö (Göteborg) (A116)

COMPARATIVE STUDY OF BMPs AND DELIVERY STRATEGIES

Ugo Ripamonti (Witwatersrand, Parktown) (A117)

THE INDUCTION OF BONE FORMATION BY BMPs IN NON-HUMAN AND HUMAN PRIMATES

Ernst Hunziker (Bern) (A118)

THE IMPORTANCE OF THE MODE OF GROWTH-FACTOR DELIVERY IN BMP-2-INDUCED BONE-TISSUE ENGINEERING

William Carlson (Quebec / Boston, MA) (A119)

NOVEL PEPTIDE AGONISTS OF BMP SIGNALING: A POTENTIAL THERAPY FOR PROGRESSIVE RENAL FIBROSIS IN CHRONIC KIDNEY INJURY

Thomas Willnow (Berlin)
LRP2 PROMOTES ADULT NEUROGENESIS THROUGH SUPPRESSION OF BMP4 SIGNALING

Lovorka Grgurevic (Zagreb) (A75) with ESF support

BONE MORPHOGENETIC PROTEIN(BMP)1-3 ISOFORM OF BMP1 GENE CIRCULATES AND REGULATES KIDNEY FUNCTION

Noreen S. Cunningham lecture
Introduction by Hari Reddi
Petra Knaus (Berlin)

DYNAMICS IN BMP SIGNALING - DYNAMICS IN BMP RESEARCH

Social program during the free afternoon

Excursions
All busses leave from Provinciehuis
12:45 departure to Bruges      - bus leaves from Bruges at 17:00
13:00 departure to Ghent       - bus leaves from Ghent at 17:15
13:30 departure to Brussels    - bus leaves from Brussels at 17:45

Conference Dinner